A total pancreatectomy is is very major surgery that involves the removal of the whole pancreas as well as your duodenum, part of the stomach, the gallbladder, part of your bile duct, the spleen, and many of the surrounding lymph nodes. This operation is not often carried out as it has not been found to be any more effective for survival than either the Whipple’s procedure or the Pylorus Preserving Pancreatoduodenectomy (‘PPPD’) procedure.
There are some conditions for which it is used; for example, when tumours are found in more than one location in the pancreas, when tumours extend along the pancreatic duct, and some specific and rare types of pancreatic tumour including pre-cancerous IPMNs (intraductal papillary mucinous neoplasms).
Total Pancreatectomy (before):
Total pancreatectomy (after):